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Phys. Rev. Lett. 93, 028102 (2004) [4 pages]

Oxygen Saturation-Dependent Absorption and Scattering of Blood

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Dirk J. Faber1, Maurice C. G. Aalders1, Egbert G. Mik2, Brett A. Hooper3, Martin J. C. van Gemert1, and Ton G. van Leeuwen1,4
1Laser Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
2Department of Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
3Department of Biomedical Engineering and The Center for Emerging Cardiovascular Technologies, Duke University, Durham, North Carolina 27708-0319, USA
4Biophysical Engineering, Biomedical Technology Institute, University of Twente, Enschede, The Netherlands

Received 2 October 2003; published 8 July 2004

We report on the scattering properties of oxygenated and deoxygenated whole blood from 250 to 1000 nm. We determine the complex refractive index of oxygenated and deoxygenated hemoglobin using a Kramers-Kronig analysis and optical coherence tomography measurements. Combining these data with Mie theory, the scattering properties are calculated. The strong oxygen saturation dependent scattering effects should be taken into account in the data analysis of optical oxymetry.


©2004 The American Physical Society

URL: http://link.aps.org/doi/10.1103/PhysRevLett.93.028102
DOI: 10.1103/PhysRevLett.93.028102
PACS: 87.64.Cc, 42.25.Bs, 78.20.–e

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