Phys. Rev. Lett. 95, 228101 (2005) [4 pages]Compaction of Single-Chain DNA by Histone-Inspired Nanoparticles
Anatoly A. Zinchenko1, Kenichi Yoshikawa1, and Damien Baigl1,2 * Received 6 May 2005; published 21 November 2005 We elaborated a versatile experimental model of chromatin which consists of a single chain of long duplex DNA that interacts with well-defined cationic nanoparticles of various sizes. We found that the DNA compaction by nanoparticles is stepwise and progressive at the single-chain level. It is controlled by the ability of DNA to wrap nanoparticles, which is more efficient for larger particles and, similar to DNA-histone interaction, is optimal at a physiological salt concentration. ©2005 The American Physical Society
URL: http://link.aps.org/doi/10.1103/PhysRevLett.95.228101 * Electronic address: damien.baigl@ens.fr [ Abstract | Previous article | Next article | Issue 22 ] |
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