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Physical Review Letters – 4 June 2004
Volume 92, Issue 22

Energy landscape of a DNA-protein spool unfolding under tension. The transition pathway from the folded state (a) to the unfolded state (g) goes over a large barrier at (e), the result of interplay between DNA stiffness and spool geometry. This barrier explains the "kinetic inertness" of DNA spools observed in various single-molecule experiments, ranging from nucleosoms to DNA toroids. [I. M. Kulić and H. Schiessel, Phys. Rev. Lett. 92, 228101 (2004)]

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